The R235 road between Castlefinn and Castlederg is blocked this afternoon following a crash.
Gardaí are attending the scene. Motorists are advised to follow an alternative route.
There are significant delays in the area as a result of roadworks between Letterkenny and Lifford.
Two sets of roadworks are ongoing on the N14, one near the N13 junction at Drumoghill and the other by the Raphoe turn-off.
Motorist should leave extra time if travelling in the area.