Ms Kane, a hugely respected leader in education, was a native of Mountcharles.
She took over from former VEC boss Sean O’Longain who retired a number of years ago.
Ms O’Kane, who was based at the VEC offices in Letterkenny, had been battling illness for a number of months.
Tributes have been flowing in for Ms Kane who was considered a leader in education reform across the country.
As well as a former Education Officer within Donegal VEC, Ms Kane was a former principal of the Abbey Voctional School in Donegal Town.
An official notice has been posted on the Donegal VEC website expressing the organisation’s sympathy with Ms Kane’s family.
Funeral arrangements have yet to be made.