Three cars were involved in the smash on the Fintown Road, Ballybofey, at breakfast time.
Two children and two adults were hurt in the incident.
Gardai say the road has now reopened.
Four ambulance crews were at the scene.
“It looks an horrific incident,” said one eye-witness.
“Thankfully no-one has been killed. There are two walking wounded and crews are dealing with them.
“Fire officers are cutting one other person out of a vehicle.”
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