The Tyrone side led by five points at half time, 1-06 to 0-04, with Reilly netting.
Milford’s hopes of staging a comeback were quickly erased as Killeshil dominated in the second half.
David Curley found the net for Milford towards the end, only to see the Tyrone side net at the other end with the next play.
Final Score Milford 1-08, 2-14.