Gardai have appealed to motorists traveling from Letterkenny to Ramelton in both directions to travel via Kilmacrennan following a serious accident.
The single vehicle accident at Castleshanaghan has left a young man in a critical condition. A woman was also injured.
Gardai are at the scene and the road will be closed until further notice.
Gardai have appealed to motorists to avoid the road altogether until further notice.