The men, who cannot be named to protect the identity of alleged victims, faced various charges.
One of the men was charged five counts of rape and eight counts of sexual assault in County Donegal between 1999 and 2003.
The other man was charged with one count of rape and six counts of sexual assault in County Donegal between 1999 and 2012.
No other details were given at Letterkenny District Court today and reporting restrictions were imposed to protect the identity of alleged victims.
Judge Paul Kelly adjourned the hearing for two months to allow a book of evidence to be served.