Three confirmed cases of Covid-19 have been recorded at Letterkenny University Hospital.
One case was confirmed on Friday and a further two were recorded on Sunday.
The data, issued by the HSE, comes after a long period of Letterkenny Hospital having zero Covid-19 patients.
As of Sunday night, none of the three patients with Covid-19 were in critical care.
Twenty-five new cases of Covid-19 have been confirmed in Donegal in the past two weeks.
The total number of cases in the county since the outbreak began has now reached 512. The figure is valid to Friday 21st August.
As of 8pm yesterday, there was a total of 28 Covid-19 cases in Irish hospitals nationwide.
The National Public Health Emergency Team yesterday confirmed no new deaths and 61 newly confirmed cases of COVID-19.
Dr. Ronan Glynn, Acting Chief Medical Officer, Department of Health said; “I know that at times we can all feel powerless against COVID-19. But we are not. Each of us has a range of simple tools at our disposal – knowing the risks, washing our hands, not touching our faces, keeping physically distant, avoiding crowds, limiting visitors to our homes, and wearing a face covering.
“But the most powerful tool of all remains our solidarity with one another – by encouraging each other to stick with the basic measures and by continuing to act and adapt together we can suppress the transmission of this virus once again.”