The number of people hospitalised with Covid-19 at Letterkenny University Hospital has increased to 32.
The figure, recorded at 8pm on Sunday night, is up from 26 over the previous two days.
HSE data shows that one patient with Covid-19 is in critical care and another patient with a suspected case of the virus is also critical.
There were no critical care beds available at the hospital last night, while 31 general care beds were marked available.
Donegal recorded another jump in Covid-19 cases on Sunday, with 52 more infections reported by NPHET. There have been 420 new cases of the virus in Donegal in the past two weeks.
Dr Tony Holohan, Chief Medical Officer, the Department of Health said: “Every indicator of disease severity is moving in the wrong direction, more rapidly than we had anticipated. We have particularly strong concerns about the prospect of inter-generational mixing around the festive season.
“On 11th December the 7-day incidence rate for people aged 19-44 was 106 per 100,000 population, by yesterday this rate had more than doubled to 217 per 100,000. If these younger people come into contact with their loved ones over the age of 65, we could see a spike in infections in this more vulnerable group.
“This would lead to very a serious pattern of disease, hospitalisations, ICU admissions and unnecessary deaths.”
