The two sides have made bright starts to the campaign and both are still in contention for a playoff position, so the game takes on added significance.
At the beginning of the season, supporters of each county would have been delighted if told that they would be in this position are having played four games.
Derry have a new manager in John Brennan while Donegal also looked to be rebuilding under Jim McGuiness.
Derry were particularly impressive away to Kildare but were surprisingly beaten by Laois at home on their next outing. They got their season back on the rails with a victory away to Sligo last weekend, although they were made to work hard for the points.
Donegal defeated Meath last weekend and have plenty to shout about after four games. They will have plenty of confidence going to Derry this weekend and will fear no-one in this section.
McGuinness will be hoping he can get plenty of scores from the ever reliable Michael Murphy while Derry will be dependent on Paddy Bradley up front.
If Donegal can keep Bradley quiet, then they can add to their win in Meath last weekend and push for a place back in Division One again.
*A full report on the game will be carried later this evening.