The crash happened just after 9.30pm at Drumnahoe, between the Polestar and Dry Arch Roundabouts.
The stretch of road has been the scene of numerous accidents in recent months.
Earlier this year a young man died following a crash approximately 200 yards from tonight’s crash.
Two ambulances and the Gardai are at the scene of tonight’s crash.
At this stage it is unclear if anyone has been seriously injured.