A number of leading players including Neil Gallagher, Kevin Cassidy, Daniel McLaughlin and Kevin Mulhern are all believed to have been struck down with the condition.
The four players all missed this week’s training session in Castlefin and it is unknown if any will take part in the game at this stage.
In fact, it is likely that McGuinness will delay naming his team until just before the game at Healy Park in Omagh throw-in 2pm.
The game will be a much anticipated curtain-raiser for McGuinness’ senior managerial career after a successful spell as Under 21 boss.
McGuinness, who is highly-rated amongst a number of pundits and former players as having the potential to make things happen for Donegal, knows what he wants from his team.
He said he needs to get his players showing some spark again and playing for the jersey of their county.
The last times the sides met Donegal came out on top in the early stages of the McKenna Cup with the help of a stunning 2-09 contribution from Glenswilly man Michael Murphy which helped Donegal win the encounter.