The Donegal ‘keeper was forced out of the action in the 38th minute at Villa Park after racing out of his goal to halt a United attack.
Given immediately reached for his left hamstring and it quickly became apparent the 35-year-old would be unable to continue.
“I’m not sure but I think Shay had a little tweak in his hamstring. Hopefully it’s a grade one (tear) and will heal really quickly,” said Villa manager Alex McLeish in an interview with Sky Sports.
“Stand-in keeper Brad Guzan can be proud of the way he came in in those circumstances.”
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